IMPACTS: 

• Addition of four new CYP isoforms for SoM predictions (2A6, 2B6, 2C8, and 2E1).
• Use of SASA correction factor to improve activation energy assignment.

SELECT:

• Use of Tversky index in addition to Tanimoto coefficient for seach similarity.

CONVERT:

• Can convert 2D to 3D while keeping the input hydrogens.
• Can force protonation/deprotonation and can specifiy maximum protonation state for any given molecule.

REACT2D:

• Additional aromatic groups recognized by React2D/Finders.
• Improvement of stereochemistry assignment in difficult cases.

PREPARE:

• Chain name assignment when missing in PDB file.
• A ligand can be provided to identify the binding site (and keep water molecules in the vicinity).

General Improvements: 

• Multiple bugs fixed.
• Cosmetic changes and output cleanup.