{"id":2922,"date":"2021-09-28T07:40:49","date_gmt":"2021-09-28T14:40:49","guid":{"rendered":"https:\/\/molecularf.wpenginepowered.com\/?p=2922"},"modified":"2026-09-18T17:54:49","modified_gmt":"2026-09-19T00:54:49","slug":"obtention-dun-financement-de-1-million-de-dollars","status":"publish","type":"post","link":"https:\/\/molecularforecaster.com\/fr\/obtention-dun-financement-de-1-million-de-dollars\/","title":{"rendered":"Obtention d’un financement de 1 million de dollars"},"content":{"rendered":"\n

Molecular Forecaster poursuit sa qu\u00eate d'acc\u00e9l\u00e9ration de la d\u00e9couverte de m\u00e9dicaments avec deux nouveaux partenariats public-priv\u00e9<\/b><\/h3>\n

L'entreprise et ses partenaires ont obtenu 1 million de dollars canadiens pour appliquer et am\u00e9liorer le logiciel de conception virtuelle de m\u00e9dicaments d'MFI pour soutenir la recherche pr\u00e9clinique ciblant les bact\u00e9ries r\u00e9sistantes aux antibiotiques et la st\u00e9atose h\u00e9patique non alcoolique.<\/i><\/p>\n

MONTR\u00c9AL, QU\u00c9BEC, 28 septembre 2021 - Molecular Forecaster Inc. (MFI) est heureuse d'annoncer qu'elle a obtenu un financement pour poursuivre le d\u00e9veloppement de son logiciel de conception de m\u00e9dicaments bas\u00e9 sur la structure, offrir ses services de recherche et s'\u00e9tendre \u00e0 de nouveaux cr\u00e9neaux de cibles m\u00e9dicamenteuses. Le financement soutient l'optimisation des algorithmes propri\u00e9taires de la soci\u00e9t\u00e9 et permettra \u00e0 MFI et \u00e0 ses partenaires d'acc\u00e9l\u00e9rer la conception de petites mol\u00e9cules contre des cibles biologiques li\u00e9es \u00e0 diverses maladies, y compris les r\u00e9cepteurs coupl\u00e9s aux prot\u00e9ines G (GPCR), les m\u00e9talloenzymes, les facteurs de transcription et les acides nucl\u00e9iques.<\/p>\n

En tant qu'organisme de recherche sous contrat sp\u00e9cialis\u00e9 dans la d\u00e9couverte de m\u00e9dicaments in silico, MFI poss\u00e8de une expertise dans les domaines de la d\u00e9couverte de m\u00e9dicaments, de la m\u00e9canique quantique, de la dynamique mol\u00e9culaire, de la chimio-informatique et de l'intelligence artificielle (IA). Cela signifie qu'MFI peut offrir \u00e0 ses clients - dont beaucoup sont de petites entreprises de biotechnologie sp\u00e9cialis\u00e9es dans des domaines de recherche qui ne re\u00e7oivent pas beaucoup d'attention - une synth\u00e8se unique de science, de logiciel et de service pour acc\u00e9l\u00e9rer leur processus de d\u00e9couverte de m\u00e9dicaments \u00e0 un stade pr\u00e9coce.<\/p>\n

\"Le COVID a, \u00e0 bien des \u00e9gards, normalis\u00e9 une approche de la d\u00e9couverte de m\u00e9dicaments qu'MFI a adopt\u00e9e depuis son lancement en 2010 : trouver des moyens de faire le plus grand bien en un minimum de temps avec les meilleurs outils disponibles\", d\u00e9clare Josh Pottel, pr\u00e9sident-directeur g\u00e9n\u00e9ral dMFI. \"Nous constatons une demande de plus en plus forte pour acc\u00e9l\u00e9rer la d\u00e9couverte de m\u00e9dicaments \u00e0 l'aide d'approches computationnelles. Nous pensons que la combinaison de notre connaissance du domaine et de notre exp\u00e9rience de la recherche fait d'MFI un partenaire de choix pour les petites et moyennes entreprises de biotechnologie qui cherchent \u00e0 r\u00e9duire leurs co\u00fbts de recherche pr\u00e9clinique, \u00e0 \u00e9tendre leurs capacit\u00e9s et \u00e0 am\u00e9liorer leurs taux de r\u00e9ussite.\"<\/p>\n

Dans le cadre du programme de G\u00e9nome Qu\u00e9bec Programme d'int\u00e9gration de la g\u00e9nomique<\/a>Le partenariat public-priv\u00e9 d'MFI avec l'Universit\u00e9 McGill, le Laboratoire McKeague<\/i> de chimie g\u00e9nomique et du laboratoire Mittermeier de structure, de fonction et de dynamique biomol\u00e9culaires a obtenu 400 000 dollars pour un projet de deux ans visant \u00e0 d\u00e9velopper un pipeline de conception rationnelle et de criblage in vitro afin de d\u00e9couvrir de nouvelles classes d'antibiotiques ciblant l'acide ribonucl\u00e9ique (ARN). La r\u00e9sistance bact\u00e9rienne aux antibiotiques constitue une menace importante pour la sant\u00e9 publique mondiale et, jusqu'\u00e0 pr\u00e9sent, la capacit\u00e9 \u00e0 d\u00e9velopper de nouvelles th\u00e9rapies a \u00e9t\u00e9 limit\u00e9e, en partie \u00e0 cause du manque d'options logicielles permettant d'acc\u00e9l\u00e9rer leur d\u00e9couverte. MFI pr\u00e9voit que le logiciel d\u00e9velopp\u00e9 dans le cadre de ce projet pourra \u00eatre utilis\u00e9 pour mettre au point des m\u00e9dicaments destin\u00e9s \u00e0 une large gamme de bact\u00e9ries ainsi que d'autres produits th\u00e9rapeutiques qui interagissent avec l'ARN.<\/p>\n

\"Nous avons d\u00e9sesp\u00e9r\u00e9ment besoin d'outils informatiques pour mod\u00e9liser l'ARN et cribler les mol\u00e9cules qui agissent sur l'ARN, ce qui rend ce projet avec MFI si passionnant\", d\u00e9clare Maureen McKeague, professeur adjoint de pharmacologie et de chimie \u00e0 McGill. \"Nous esp\u00e9rons prouver l'efficacit\u00e9 du logiciel d'MFI dans la d\u00e9couverte de m\u00e9dicaments ciblant l'ARN, tout en \u00e9valuant les petites mol\u00e9cules retenues comme antibiotiques potentiels ciblant les riboswitches.<\/p>\n

Avec le soutien d'un consortium de recherche biopharmaceutique, le CQDM <\/a>MFI a \u00e9galement obtenu un investissement pour un projet en partenariat avec AR Metabolic Inc. une soci\u00e9t\u00e9 de biotechnologie en phase de d\u00e9marrage qui d\u00e9veloppe des th\u00e9rapies pour la st\u00e9atose h\u00e9patique non alcoolique (NAFLD) et la st\u00e9atoh\u00e9patite non alcoolique (NASH), et le laboratoire d'endocrinologie mol\u00e9culaire de l'Universit\u00e9 McGill. Le projet, d'une dur\u00e9e de trois ans, est ax\u00e9 sur le d\u00e9veloppement d'une conception rationnelle et d'un programme de criblage in vitro ciblant une prot\u00e9ine cl\u00e9 impliqu\u00e9e dans le m\u00e9tabolisme des sucres et des graisses.<\/p>\n

\"G\u00e9n\u00e9ralement, la d\u00e9couverte de nouveaux m\u00e9dicaments se fait par le criblage de biblioth\u00e8ques de compos\u00e9s. Mais le criblage de biblioth\u00e8ques n\u00e9cessite beaucoup de temps et de ressources\", explique Laurent Amar, PDG d'AR Metabolic. \"Avec MFI, nous pouvons utiliser un logiciel utilisant l'intelligence artificielle pour identifier de nouvelles interactions entre les mol\u00e9cules et les cibles - une approche innovante qui nous aide \u00e0 acc\u00e9l\u00e9rer nos efforts pour trouver un rem\u00e8de aux probl\u00e8mes de sant\u00e9 qui affectent pr\u00e8s d'un quart de la population mondiale.\"<\/p>\n

La subvention de 600 000 $ accord\u00e9e \u00e0 ce projet comprend 300 000 $ provenant du minist\u00e8re de l'\u00c9conomie et de l'Innovation<\/a> du Qu\u00e9bec par l'interm\u00e9diaire de son agence d'investissement, Investissement<\/a> Qu\u00e9bec<\/a>.<\/p>\n

\" Gr\u00e2ce \u00e0 son expertise en intelligence artificielle et en technologie quantique, le Qu\u00e9bec poss\u00e8de les atouts n\u00e9cessaires pour pousser encore plus loin la recherche de nouveaux m\u00e9dicaments \", a d\u00e9clar\u00e9 Pierre Fitzgibbon, ministre de l'\u00c9conomie et de l'Innovation et ministre responsable du D\u00e9veloppement \u00e9conomique r\u00e9gional. \"Pour devenir des leaders mondiaux en sciences de la vie, nous devons continuer \u00e0 miser sur nos secteurs de pointe et sur la cr\u00e9ativit\u00e9 de nos chercheurs.\"<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 ###<\/b><\/p>\n

\u00c0 propos de Molecular Forecaster Inc.<\/b><\/p>\n

Molecular Forecaster Inc. (MFI) est une soci\u00e9t\u00e9 de chimie computationnelle sp\u00e9cialis\u00e9e dans la d\u00e9couverte de m\u00e9dicaments, la m\u00e9canique quantique, la dynamique mol\u00e9culaire, la chimio-informatique et l'intelligence artificielle. Proposant des logiciels propri\u00e9taires, des algorithmes et des services de recherche contractuelle de pointe, MFI travaille avec des organisations qui cherchent \u00e0 acc\u00e9l\u00e9rer la d\u00e9couverte pr\u00e9clinique de m\u00e9dicaments, qu'il s'agisse de jeunes entreprises de biotechnologie ou d'entreprises pharmaceutiques bien \u00e9tablies. Fond\u00e9e en 2010, MFI est issue de recherches men\u00e9es \u00e0 l'Universit\u00e9 McGill et fait aujourd'hui partie du programme Acc\u00e9l\u00e9ration Qu\u00e9bec<\/a> au sein du Centre de bioinnovations adMare \u00e0 Montr\u00e9al, Canada.<\/p>\n

Contact presse<\/b>
Megan Helmer
Puzzlewood Communication Inc.
T\u00e9l : +1.604.240.5223<\/p>\n

megan@puzzlewood.ca<\/u><\/p>\n

Contact pour le d\u00e9veloppement des affaires<\/b>
Geoffrey Crampton
T\u00e9l. 1.514-265-4363<\/p>\n

geoff.crampton@molecularforecaster.com<\/u><\/p>\n<\/div><\/div><\/div>

<\/span><\/div><\/div><\/div>
<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

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